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Recombinant Human LILRB3/CD85a/ILT5(His-Avi Tag)

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翌圣生物科技(上海)股份有限公司更新時(shí)間：2024-12-24 09:03:45

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詳細(xì)介紹

Leukocyte immunoglobulin-like receptor subfamily B (LILRB3), also known as ILT5, LIR3, and CD85a, is an immunoglobulin superfamily member that is involved in immune regulation. In mouse and rat, the LILRB3 gene encodes the PIR-B protein which has six Ig-like domains. Rodent PIR-B and human LILRB3 share 55% aa sequence identity within common regions of their ECDs. LILRB3 is expressed on the surface of peripheral monocytes, neutrophils, eosinophils, basophils, and mast cell progenitors. Triggering of LILRB3 inhibits the activation of macrophages, mast cells, neutrophils, basophils, and B cells. LILRB3 can also bind to ligands exposed on necrotic tumor cells.

產(chǎn)品性質(zhì)

別名（Synonyms）	CD85a, ILT5, ILT-5, LILRB3, LIR3, LIR3CD85A, LIR-3MGC138403, PIRB, HL9
Uniprot No.	O75022-1
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）	Recombinant Human LILRB3 / CD85a / ILT5 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Gly24-Glu443.
分子量(Molecular Weight)	Approximately 50 kDa. Due to glycosylation, the protein migrates to 60-72 kDa based on Tris-Bis PAGE result.
外觀(Physical Appearance）	Sterile Filtered White lyophilized (freeze-dried) powder.
純度（Purity）	> 95% as determined by SDS-PAGE and HPLC
活性（Activity）	ELISA Data: Immobilized Human LILRB3, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-LILRB3 Antibody, hFc Tag with the EC₅₀ of 27.3 ng/mL determined by ELISA.
內(nèi)毒素（Endotoxin）	< 1.0 EU per 1μg of the protein by the LAL method.
制劑（Formulation）	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
復(fù)溶（Reconstitution）	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL` is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.