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Recombinant Mouse SDF-1β/CXCL12β

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翌圣生物科技(上海)股份有限公司更新時(shí)間：2024-12-24 09:03:45

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同類(lèi)產(chǎn)品SDF-1βCXCL12β(3件)

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Recombinant Rat SDF-1β/CXCL12β

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詳細(xì)介紹

CXCL12, also known as SCYB12, PBSF and SDF-1 beta, is an 8.3 kDa, heparin-binding member of the CXC (or alpha-) family of chemokines. SDF-1 is highly conserved between species, mouse CXCL12β shares approximately 92 % amino acid sequence identity with human CXCL12β. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete amino acids in the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. Although alpha and beta isoforms show similar activity, SDF-1 alpha is differentially processed, and different cells secrete the two isoforms. SDF-1 alpha and beta are reported to be monomers at neutral pH and physiologic ionic strength.

Product Properties

Synonyms	CXCL12/SDF-1 beta, TPAR1, PBSF, TLSF
Accession	P40224
GeneID	20315
Source	E.coli-derived mouse SDF-1β/CXCL12β protein, Lys22-Met93.
Molecular Weight	Approximately 8.5 kDa.
AA Sequence	KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM
Tag	None
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	>97% by SDS-PAGE and HPLC analyses.
Biological Activity	The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/mL. Fully biologically active when compared to standard.
Endotoxin	< 1.0 EU per 1μg of the protein by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.