• <strike id="cseqw"><noscript id="cseqw"></noscript></strike>
  • <strike id="cseqw"></strike>

    儀器網(wǎng)(yiqi.com)歡迎您!

    | 注冊(cè) 登錄
    網(wǎng)站首頁(yè)-資訊-專題- 微頭條-話題-產(chǎn)品- 品牌庫(kù)-搜索-供應(yīng)商- 展會(huì)-招標(biāo)-采購(gòu)- 社區(qū)-知識(shí)-技術(shù)-資料庫(kù)-方案-產(chǎn)品庫(kù)- 視頻

    產(chǎn)品中心

    當(dāng)前位置:儀器網(wǎng)>產(chǎn)品中心> 翌圣生物科技(上海)股份有限公司>細(xì)胞因子>白介素>Recombinant Human IL-36α,153aa
    收藏  

    Recombinant Human IL-36α,153aa

    立即掃碼咨詢

    聯(lián)系方式:400-611-1883

    聯(lián)系我們時(shí)請(qǐng)說(shuō)明在儀器網(wǎng)(www.vietnamtrade.org)上看到的!

    掃    碼    分   享
    為您推薦

    詳細(xì)介紹

    Human IL-36 alpha, previously called IL-1F6 and FIL1 epsilon  (family of IL-1 member epsilon), is a member of the IL-1 family which includes IL-1 beta, IL-1 alpha, IL-1ra, IL-18, and novel family members IL-36 Ra (IL-1F5), IL-36 beta (IL-1F8), IL-36 gamma (IL-1F9), IL-37 (IL-1F7) and IL38 (IL1F10) . All family members show a 12  beta strand, beta -trefoil configuration, and are believed to have arisen from a common ancestral gene. IL-36 alpha is an 1822 kDa, 158 amino acid (aa) intracellular and secreted protein that contains no signal sequence, no prosegment and no potential from Nlinked glycosylation sites. It can be released in response to LPS and the cell ATPinduced activation of the P2X7 receptor. A 120 aa isoform missing aa 138 has been reported. Human IL36 alpha (aa 6  158) shares 5768% aa sequence identity with mouse, rabbit, equine and bovine IL36 alpha and 2757% aa sequence identity with other novel IL1 family members. IL36 alpha is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine . It is expressed by monocytes, B and T cells. The receptor for IL36 alpha is a combination of IL1 Rrp2 (also called IL1RL2 or IL1 R6), mainly found in epithelia and keratinocytes, and the widely expressed IL1 RAcP. IL-36 alpha, beta, and gamma all activate NF-kappa B and MAPK pathways in an IL1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL-8. IL-36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL36 alpha in skin keratinocytes produces epidermal hyperplasia. IL-36 alpha is present in kidney tubule epithelia, and it is highly expressed in intubulointerstitial lesions in mouse models of chronic glomerulonephritis, lupus nephritis and diabetic nephritis.

     

    Product Properties

    Synonyms

    FIL1 epsilon, IL-1 epsilon, IL-1F6, IL-1H1

    Accession

    Q9UHA7

    GeneID

    27179

    Source

    E.coli-derived human Interleukin-36 alpha protein, Lys6-Phe158.

    Molecular Weight

    Approximately 17.1 kDa.

    AA Sequence

    KIDTPQQGSI QDINHRVWVL QDQTLIAVPR KDRMSPVTIA LISCRHVETL EKDRGNPIYL GLNGLNLCLM CAKVGDQPTL QLKEKDIMDL YNQPEPVKSF LFYHSQSGRN STFESVAFPG WFIAVSSEGG CPLILTQELG KANTTDFGLT MLF

    Tag

    None

    Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

    Purity

    > 95% by SDS-PAGE and HPLC analyses.

    Biological Activity

    Fully biologically active when compared to standard. The ED50 as determined by inducing IL-8 secretion in human preadipocytes is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg.

    Endotoxin

    < 1.0 EU per 1μg of the protein by the LAL method.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, pH 8.0, 0.1% Tween 80.

    Reconstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.

     

    Shipping and Storage

    The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

     

    Cautions

    1. Avoid repeated freeze-thaw cycles.

    2. For your safety and health, please wear lab coats and disposable gloves for operation.

    3. For research use only.

    HB220225

     

    廠商推薦產(chǎn)品

    在線留言

    換一張?
    取消
    精品无码在线,九九精品综合人人爽人妻,亚洲一区在线尤物,伊人网在线18禁
  • <strike id="cseqw"><noscript id="cseqw"></noscript></strike>
  • <strike id="cseqw"></strike>