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Recombinant Human CyP-D

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翌圣生物科技(上海)股份有限公司更新時間：2024-12-24 09:03:45

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詳細介紹

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Product Properties

Synonyms	PPIF, Cyclophilin F, CyP-M, Rotamase F
Accession	P30405
GeneID	10105
Source	E.coli-derived Human CyP-D, Cys30-Ser207.
Molecular Weight	Approximately 18.9 kDa.
AA Sequence	CSKGSGDPSS SSSSGNPLVY LDVDANGKPL GRVVLELKAD VVPKTAENFR ALCTGEKGFG YKGSTFHRVI PSFMCQAGDF TNHNGTGGKS IYGSRFPDEN FTLKHVGPGV LSMANAGPNT NGSQFFICTI KTDWLDGKHV VFGHVKEGMD VVKKIESFGS KSGRTSKKIV ITDCGQLS
Tag	None
Physical Appearance	Sterile colorless liquid.
Purity	> 95% by SDS-PAGE and HPLC analyses.
Biological Activity	Data Not Available.
Endotoxin	< 0.1 EU per 1μg of the protein by the LAL method.
Formulation	Supplied as a 0.2 μm filtered solution in PBS, pH7.4, with 1 mM DTT, 10 % glycerol.